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In his final year in office, Trump consistently undermined the health guidance of his task force, encouraging the public to pushback on lockdowns imposed by Democratic governors, publicly questioning the efficiency of face masks and holding campaign rallies that violated state capacity limits, among other things.

Trump's COVID Task Force Vowed to Quit if One Doctor Was Fired (msn.com)

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In the news again:

The latest findings come from a review of three rigorous clinical trials conducted in Brazil, Canada, and the U.S. that points to a tie between fluvoxamine and a reduced risk of hospitalizations, according to the research, which was published April 6 in JAMA Network Open. 

Can a decades-old antidepressant keep COVID-19 patients out of the hospital? (msn.com)

 

Long COVID-19 may be caused by abnormally suppressed immune system in some people: UCLA-led study.

Long COVID-19 may be caused by abnormally suppressed immune system in some people: UCLA-led study (msn.com)

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Kamala Harris, vaccinated, triple boosted tests positive, no symptoms, isolated.

Big news…….

Why do we care, she ain’t gonna die.

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About 58% of Americans have been infected with COVID-19 at least once, the Centers for Disease Control found.

An estimated 75% of children age 11 and under have contracted COVID, according to the CDC study released Tuesday. 

The CDC is also working on another study, which would show that each omicron infection led to three more infections, USA Today reported. That would confirm the omicron variant was easily the most transmissible strain of the virus seen thus far.

The agency is also working on a study that would show official COVID data only captured one-third of the true case count since the beginning of the pandemic in March 2020, according to the Associated Press.

 

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There is no evidence of a link between COVID-19 vaccines and hepatitis cases in children. As stated by the UKHSA and WHO, no link between vaccines and hepatitis has been established as the majority of cases are of those who have not been vaccinated. Researchers and scientists say they are still grappling with finding the underlying cause or causes of this spike in cases, although early examinations suggest a type of adenovirus may be involved.

Fact Check: Are Child Hepatitis Cases Linked to COVID-19 Vaccines? (msn.com)

 

A study of more than 27 million people in the United States found that individuals diagnosed with COVID-19 were at a higher risk of developing type 1 diabetes than those who did not contract SARS-CoV-2 during the same period. 

The researchers reported their findings in the journal PLOS One earlier this month, saying that the risk was 42% for COVID-19 patients to develop juvenile diabetes after their bout with the coronavirus. The risk was highest at 584% among pediatric patients (under the age of 1) and elevated among older adult patients. 

After evaluating their collected data for the differences across race and ethnicity, the team found that the COVID-19-associated risk of type 1 diabetes was most pronounced in American Indian/Alaskan Native (130%), followed by Asian/Pacific Islander (101%) and Blacks (59%). 

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SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis

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Highlights

-Identification of immune correlates in a case of mRNA vaccine-associated autoimmune hepatitis

-Imaging mass cytometry identifies intrahepatic panlobular enrichment of activated cytotoxic CD8 T cells

-Flow cytometry identifies intrahepatic enrichment of activated CD8 T cells with SARS-CoV-2-specificity

-Peripheral SARS-CoV-2-specific CD8 T cell activation correlates with ALT levels

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Abstract

Background & Aims

Autoimmune hepatitis episodes have been described following SARS-CoV-2 infection and vaccination but their pathophysiology remains unclear. Here, we report the case of a 52-year-old male, presenting with bimodal episodes of acute hepatitis, each occurring 2-3 weeks after BNT162b2 mRNA vaccination and sought to identify the underlying immune correlates. The patient received first oral budesonide, relapsed, but achieved remission under systemic steroids.

Methods

Imaging mass cytometry for spatial immune profiling was performed on liver biopsy tissue. Flow cytometry was performed to dissect CD8 T cell phenotypes and identify SARS-CoV-2-specific and EBV-specific T cells longitudinally. Vaccine-induced antibodies were determined by ELISA. Data was correlated with clinical labs.

Results

Analysis of the hepatic tissue revealed an immune infiltrate quantitatively dominated by activated cytotoxic CD8 T cells with panlobular distribution. An enrichment of CD4 T cells, B cells, plasma cells and myeloid cells was also observed compared to controls. The intrahepatic infiltrate showed enrichment for CD8 T cells with SARS-CoV-2-specificity compared to the peripheral blood. Notably, hepatitis severity correlated longitudinally with an activated cytotoxic phenotype of peripheral SARS-CoV-2-specific, but not EBV-specific CD8+ T cells or vaccine-induced immunoglobulins.

Conclusions

COVID19 vaccination can elicit a distinct T cell-dominant immune-mediated hepatitis with a unique pathomechanism associated with vaccination induced antigen-specific tissue-resident immunity requiring systemic immunosuppression.

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Lay summary

Liver inflammation is observed during SARS-CoV-2 infection but can also occur in some individuals after vaccination and shares some typical features with autoimmune liver disease. In this report, we show that highly activated T cells accumulate and are evenly distributed in the different areas of the liver in a patient with liver inflammation following SARS-CoV-2 vaccination. Moreover, within these liver infiltrating T cells, we observed an enrichment of T cells that are reactive to SARS-CoV-2, suggesting that these vaccine-induced cells can contribute to the liver inflammation in this context.

Unless a 52 year old is considered a child, that deboonk was not related to the present case, and this paper is not about a statistical study.

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https://www.bmj.com/content/bmj/377/bmj.o1011.full.pdf

 

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The fact that it happened is enough. The fact that Johnson misled parliament and the nation—only admitting his involvement after being caught in the crime—carries potentially greater ramifications. Given that this deception appears to be part of a trail of dishonesty or at least a wilful “spinning” of the truth,2 and that it took place in the midst of an unprecedented public health crisis, we are more than entitled to challenge the new government rhetoric of “We got the big calls right” on covid. Indeed, it is perhaps our duty to challenge this dubious claim as we look to learn and improve our response to this pandemic and prepare for the next.

 

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https://www.bmj.com/content/bmj/377/bmj.o1037.full.pdf

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Paxlovid should be used “as part of a comprehensive strategy for vaccination, testing, and rapid treatment for patients at higher risk of progressing to more serious covid-19,” Steve Pearson, president of the Institute for Clinical and Economic Review, told The BMJ. “The key feature of the oral treatments is that they may help make administration of rapid treatment more feasible across different types of healthcare settings,” he added. Like any antimicrobial drug, including antibiotics, relying too heavily on Paxlovid increases the chances that SARS-CoV-2 will evolve to become resistant.

 

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https://www.medrxiv.org/content/10.1101/2022.04.04.22272833v1.full.pdf

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We compared the differences in trends of 14-day incidences between Helsinki and Turku among 10–12-year-olds, and for comparison, also among ages 7–9 and 30–49 by using joinpoint regression. According to our analysis, no additional effect seemed to be gained from this, based on comparisons between the cities and between the age groups of the unvaccinated children (10–12 years versus 7–9 years).

 

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Snopes in damage control mode

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Claim

In 2021, Twitter punished tweets which stated, accurately, that vaccinated people could spread COVID-19.

What's True

For several days in December 2021, Twitter's public COVID-19 misinformation policy stated effectively that it would punish users who claimed that vaccinated people could "spread or shed the virus" to others, a claim that is in fact accurate. However...

What's False

Twitter says its actual policy always related to claims that vaccinated people could spread the vaccine to others. According to the company, the use of the word "virus" in that context was merely a typo, which was corrected on Dec. 16, and did not reflect the true policy anyway.

 

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Pfizer Inc. slumped after Paxlovid, its pill for treating Covid-19, failed to show benefit as a preventive therapy in a trial. The company said late Friday that the drug failed to hit its main goal of reducing the risk that adults exposed to the coronavirus through contact with a household member would become infected. Compared with those who took a placebo, people who received Paxlovid had about a third less risk of infection, which wasn’t statistically significant.

 

Biden Administration's Muddled COVID Messaging Just Got More Confusing.

On Tuesday, Anthony Fauci, chief medical advisor to President Joe Biden, told PBS NewsHour the U.S. is "out of the pandemic phase," only to walk back that comment the next day, clarifying to the Associated Press, "by no means does that mean the pandemic is over." Then Fauci avoided the White House Correspondents' Dinner on Saturday due to COVID concerns, but a maskless Biden did attend, skipping the meal but still interacting with other attendees. 

Biden Administration's Muddled COVID Messaging Just Got More Confusing (msn.com)

 

Paywalled:

Virus mutations aren’t slowing down. New omicron subvariant proves it.

The coronavirus, SARS-CoV-2, has had billions of chances to reconfigure itself as it has spread across the planet, and it continues to evolve, generating new variants and subvariants at a clip that has kept scientists on their toes. Two-and-a-half years after it first spilled into humans, the virus has repeatedly changed its structure and chemistry in ways that confound efforts to bring it fully under control.

 

And it’s not showing signs of settling down into a drowsy old age. Even with all the changes so far, it still has abundant evolutionary space to explore, according to virologists who are tracking it closely. What that means in practical terms is that a virus that’s already extremely contagious could become even more so. The vaccines currently deployed were all based on the genomic sequence of the original strain of the virus that spread in late 2019 in Wuhan, China. They essentially mimic the spike protein of that version of the virus and trigger an immune response that is protective when the real virus shows up. But the variants that have emerged can evade many of the neutralizing antibodies that are the immune system’s front line of defense.  

https://www.washingtonpost.com/health/2022/05/01/coronavirus-more-mutations/

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Fewer than 1 in 5 US parents say they'll get Covid-19 vaccines for kids under 5 as soon as they can, survey finds.

Fewer than 1 in 5 US parents say they'll get Covid-19 vaccines for kids under 5 as soon as they can, survey finds (msn.com)

 

Omicron subvariants: New, fitter Covid-19 viruses begin to drive their own waves.

Omicron subvariants: New, fitter Covid-19 viruses begin to drive their own waves (msn.com)

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Posted (edited)

Had I kids, I would not vaccinate them for Covid, not until wise folks like Nitflegal had had more time to review outcomes. 

Edited by rmgill
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